All times shown in the programme are
Right now, it is HH:mm (dd mmm 'YY) in Turin.
09:15-09:30
Opening ceremony
Chairs: Lise Román Moltzau & Delphine Mika - ISHR Council Members
09:30-10:45
"Early Career Investigators"
Session 1
Chairs: Bernadin Ndongson Dongmo (Oslo, Norway) & Angela Della Sala (Turin, Italy)
Ana Louro (Oeiras, Portugal)
Identification of the extracellular vesicle (EV) miRNome along human induced Pluripotent Stem Cell (hiPSC)-cardiomyocyte differentiation reveals a stemness maintenance cluster driving the superior in vitro bioactivity of hiPSC-EV in mediating cardiac repair
Veneta Todorova (London, United Kingdom)
Drug-based mobilisation of mesenchymal stem/progenitor cells (MSPCs) for long term improvement of cardiac function post MI
Robert Johnson (Guildford, United Kingdom)
Human myofibroblasts promote arrhythmia in human induced pluripotent stem cell-derived cardiomyocytes through independent paracrine and contact-mediated mechanisms
Tim Stüdemann (Hamburg, Germany)
Generation of human engineered heart tissue with light activated ion channels
Marco Ronfini (Padua, Italy)
Circulating muscle-derived miR-206 links skeletal muscle dysfunction to heart sympathetic denervation
10:45-11:15
Coffee break
11:15-12:30
"Early Career Investigators"
Session 2
Chairs: Julie Pires da Silva (Aurora, USA) & Matteo Sorge (Turin, Italy)
Rima Kamel (Châtenay-Malabry, France)
Gene therapy with PDE2A improves cardiac function and limits ventricular arrhythmias in a mouse model of heart failure
Michele Russo (Turin, Italy)
Phosphoinositide 3-kinase gamma is a master regulator of doxorubicin-induced metabolic rewiring of cardiomyocytes
Theresa Brand (Würzburg, Germany)
Defects in Ca2+ handling in phospholambanR9C mice impact on excitation/contraction coupling but also on mitochondria and ER
Manuel Egle (Bern, Switzerland)
Hypothermic oxygenated perfusion (HOPE) of donor cardiac grafts obtained after circulatory death (DCD) enhances vascular and contractile function by preserving endothelial NO production
Dalma Kellermayer (Budapest, Hungary)
Increased expression of N2BA titin corresponds to more compliant myofibrils in athlete’s heart
14:00-14:15
Opening ceremony
Chairs: Lucie Carrier (ISHR-ES President), Alessandra Ghigo and Emilio Hirsch (Organising committee)
14:15-14:45
Plenary Session 1
Ketty Shwartz Award
Chair: Lucie Carrier (Hamburg, Germany)
Ursula Ravens (Freiburg, Germany)
Cardiac electrical activity – Stretching the story of ion channels and arrhythmias
14:45-15:00
Coffee break
15:00-15:50
Parallel Sessions
Session 1: Mitochondria as targets in cardiovascular disease
Chairs: Rainer Schulz (Giessen, Germany) & Nina Kaludercic (Padua, Italy)
Michael Murphy (Cambridge, United Kingdom)
Mitochondrial ROS production in cardiac IR injury
Derek Hausenloy (Singapore, Singapore)
Targeting mitochondria for cardioprotection
Christoph Maack (Würzburg, Germany)
Ion and redox regulation as a cardioprotective strategy
Session 2: New Frontiers in Cardiac Imaging
Chairs: Silvio Aime (Turin, Italy) & Amedeo Chiribiri (London, United Kingdom)
René Botnar (London, United Kingdom)
Coronary MR angiography and plaque imaging: where are we today?
Sandor Batkai (Hannover, Germany)
US imaging of heart failure for drug development
Fabien Hyafil (Paris, France)
Imaging with PET: more than the LV to look at
Session 3: Mid-Career Investigators (MCIs) Symposium
Sponsored by MappingLab
Chairs: Davor Pavlovic (Birmingham, United Kingdom) & Tania Zaglia (Padua, Italy)
Sebastiano Sciarretta (Rome, Italy)
Targeting autophagy in cardiovascular disease
Monika Gladka (Amsterdam, The Netherlands)
Novel mechanisms in cardiac regeneration
Christina Molina (Hamburg, Germany)
Novel mechanisms mediating atrial dysfunction
Olivia Johnstone (Manchester, United Kingdom) · Sponsored talk
Combined optical mapping of membrane potential and intracellular calcium to understand cardiac function
Session 4: Single cell genomics and gene editing
Sponsored by JMCC
Chairs: Lucie Carrier (Hamburg, Germany) & Sian Harding (London, United Kingdom)
Mauro Giacca (London, United Kingdom)
A toolbox for cardiac gene editing
Eva van Rooij (Utrecht, The Netherlands)
Gene editing approaches in genetic cardiomyopathy
Michela Noseda (London, United Kingdom)
Single cell gene expression to understand the dynamic architecture of the heart
15:50-16:20
Coffee break
16:20-17:20
Short oral presentations/Poster Session
Parallel group 1 (G1.01-G1.17)
Committees: Frank Lezoualc’h (Toulouse, France), Sandrine Lecour (Cape Town, South Africa)
Parallel group 2 (G2.01-G2.16)
Committees: Christoph Maack (Würzburg, Germany), Sean Davidson (London, United Kingdom)
Parallel group 3 (G3.01-G3.17)
Committees: Paula da Costa Martins (Maastricht, Netherlands), Yael Yaniv (Haifa, Israel)
17:20-17:50
Coffee break
17:50-18:35
Parallel Sessions
Session 5: Mitochondrial Ion Handling
Chairs: Peter Ferdinandy (Budapest, Hungary) & Jeanne Mialet-Perez (Toulouse, France)
Diego De Stefani (Padua, Italy)
Mitochondrial ATP-sensitive potassium channels (mitoKATP)
John Elrod (Philadelphia, PA, USA)
Mitochondrial signaling in myofibroblast formation and fibrosis
Edoardo Bertero (Würzburg, Germany)
MCU in Barth syndrome
Session 6: Redox regulation of CV function
Chairs: Petra Kleinbongard (Essen, Germany) & Derek Hausenloy (Singapore, Singapore)
Katrin Schröder (Frankfurt, Germany)
NADPH oxidases: the good and the bad
Nina Kaludercic (Padua, Italy)
Mitochondrial ROS and cardiac function: the Janus face of MAO
Joseph Burgoyne (London, United Kingdom)
From redox mechanisms to potential therapies
Session 7: Microvasculature and pulmonary hypertension
Chairs: Paula da Costa Martins (Maastricht, The Netherlands) & Michael Preedy (London, United Kingdom)
Zamaneh Kassiri (Edmonton, AB, Canada)
Disintegrin and metalloproteinases (ADAMs) as novel players in aortic aneurysm
Ralph Schermuly (Giessen, Germany)
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
Stephan Rosenkranz (Cologne, Germany)
PI3K signaling in pulmonary hypertension
Session 8: Extracellular vesicles and inflammatory mediators
Chairs: Sean Davidson (London, United Kingdom) & Sveva Bollini (Genoa, Italy)
Stephane Heymans (Maastricht, The Netherlands)
Stabilin-1: a T-cell and macrophage function modulator in viral myocarditis
Lucio Barile (Lugano, Switzerland)
Roles of exosomes in myocardial Infarction: therapy delivery tools, therapeutic targets and potential biomarkers
Ganglian Qin (Birmingham, AL, USA)
miRNA in infarcted heart-derived exosomes
13:00-14:00
Plenary Session 2
Lecture - Young Investigator Award
Chairs: Lucie Carrier (Hamburg, Germany) & Rodolphe Fischmeister (Châtenay-Malabry, France)
Jury: Christoph Maack (Würzburg, Germany), Lise Román (Moltzau, Oslo, Norway), Sean Davidson (London, United Kingdom), Zoltan Papp (Debrecen, Hungary)
Nicolo Mangraviti (Maastricht, The Netherlands)
LncRNA “Bigheart” controls a transcriptional program that auto-amplificate calcineurin-NFAT signalling in cardiac hypertrophy
Anne-Sophie Colombe (Châtenay-Malabry, France)
Anchored-PKA regulates connexin 43 GAP junction communication in the heart
Edoardo Schneider (London, United Kingdom)
High-throughput screening to identify human microRNAs that enhance CRISPR/Cas9-based cardiac precise gene editing
Mathieu Panel (Montpellier, France)
Impaired mitochondrial calcium homeostasis at the early stage of the diabetic cardiomyopathy and diastolic heart failure
Julie Pires da Silva (Aurora, CO, USA)
Serum from pediatric dilated cardiomyopathy patients promotes dysregulation of cardiolipin biosynthesis and mitochondrial dysfunction in primary cardiomyocytes
14:00-14:30
Coffee break
14:30-15:25
Parallel Sessions
Session 9: Calcium signalling in heart diseases
Sponsored by JMCC
Chairs: Ana M. Gomez (Châtenay-Malabry, France) & David Eisner (Manchester, United Kingdom)
Katharine Dibb (Manchester, United Kingdom)
Alterations to calcium handling in the atria of the failing heart
Jessica Sabourin (Orsay, France)
Orai1 inhibition preserves left ventricular function after pressure overload in mice
Jordi Heijman (Maastricht, The Netherlands)
Calcium buffering in atrial fibrillation
Session 10: New aspects of cardiac cGMP signaling
Chairs: Finn Olav Levy (Oslo, Norway) & Rodolphe Fischmeister (Châtenay-Malabry, France)
Julia Gorelik (London, United Kingdom)
Cyclic nucleotide signaling from compartmented receptors
Kjetil Wessel Andressen (Oslo, Norway)
Targeted biosensors to measure localized cGMP responses
David Paterson (Oxford, United Kingdom)
cGMP signaling regulating cardiac sympathetic neurons
Session 11: Microvasculature
Sponsored by FUJIFILM VisualSonics
Chairs: Sandrine Lecour (Cape Town, South Africa) & Petra Kleinbongard (Essen, Germany)
Ingo Hilgendorf (Freiburg , Germany)
Small cells big effects: platelets and their role in myocardial ischemia/reperfusion injury
David Grieve (Belfast, United Kingdom)
Endothelial reactive oxygen species signaling and cardiac remodelling
Lina Badimon (Barcelona, Spain)
The pathophysiological consequences of microvascular dysfunction in the heart
Philippe Trochet (Amsterdam, The Netherlands) · Sponsored talk
Novel tools for left ventricular cardiac function correlation with myocardial oxygen saturation level
Session 12: Metabolic signaling in cardiovascular diseases
Chairs: Thomas Krieg (Cambridge, United Kingdom) & Renéè Ventura-Clapier (Châtenay-Malabry, France)
Laetitia Pereira (Châtenay-Malabry, France)
Ca2+ signaling alteration in type 2 diabetes: is there gender differences?
Heiko Bugger (Graz, Austria)
Sirtuins and mitochondria
Massimiliano Mazzone (Leuven, Belgium)
Macrophage functions during ischemic and non-ischemic muscle repair
15:25-15:55
Coffee break
15:55-16:55
Short oral presentations/Poster Session
Parallel group 4 (G4.01-G4.17)
Committees: Nina Kaludercic (Padua, Italy), Lucie Carrier (Hamburg, Germany)
Parallel group 5 (G5.01-G5.17)
Committees: Lise Román Moltzau (Oslo, Norway), Zoltan Papp (Debrecen, Hungary)
Parallel group 6 (G6.01-G6.16)
Committees: Mauro Giacca (London, United Kingdom), Rodolphe Fischmeister (Châtenay-Malabry, France)
16:55-17:25
Coffee break
17:25-18:20
Parallel Sessions
Session 13: Gene and protein regulation in cardiac disease
Chairs: Alessandro Bertero (Seattle, USA) & Esther Creemers (Amsterdam, The Netherlands)
Thomas Vondriska (Los Angeles, CA, USA)
Targeting epigenomes in cardiovascular disease
Wolfgang Linke (Münster, Germany)
Posttranslational control of truncated titin proteins in cardiomyocytes from DCM patients
Mirko Völkers (Heidelberg, Germany)
mRNA metabolism and translational control in cardiovascular disease
Session 14: Cancer and heart failure
Chairs: Eric Morel (Châtenay-Malabry, France) & Pietro Ameri (Genoa, Italy)
Wouters Meijers (Groningen, The Netherlands)
Interplay between cardiovascular disease and cancer
Gavin Oudit (Edmonton, AB, Canada)
PI3Kalpha pathway inhibiton in Cardio-Oncology
Paul Burridge (Chicago, IL, USA)
Modeling cardiotoxicity with iPSC
Session 15: Aging and regeneration
Chairs: Mauro Giacca (London, United Kingdom) & Thomas Eschenhagen (ISHR-Intl President - Hamburg, Germany)
Loren Field (Indianapolis, IN, USA)
New concepts in cardiac regeneration – A historical perspective
Nadia Mercader (Bern, Switzerland)
Models to crack the code of organ regeneration
Jeanne Mialet-Perez (Toulouse, France)
Non-classical mechanisms of senescence in the aging heart
Session 16: Protein modification in cardiac disease
Sponsored by Ionoptix
Chairs: Giulio Agnetti (Baltimore, USA) & Christoph Maack (Würzburg, Germany)
Gary Lopaschuk (Edmonton, AB, Canada)
Non-histone protein acetylation in the regulation of cardiac metabolism and function
Luc Bertrand (Louvain, Belgium)
Targeting O-GlcNAcylation to prevent cardiac hypertrophy development
Friederike Cuello (Hamburg, Germany)
Oxidant-mediated regulation of protein kinase activity
Diederik Kuster (Amsterdam, The Netherlands) · Sponsored talk
Kinase inhibitor screening to uncover novel modulators of contraction and relaxation
18:20-18:50
Coffee break
18:50-19:20
Plenary Session 3
President Distinguished Lecture
Chair: Thomas Eschenhagen (ISHR-Intl President - Hamburg, Germany)
Evangelia (Litsa) Kranias (Cincinnati, OH, USA)
Calcium cycling circuits in cardiac function and survival
13:00-14:00
ISHR-ES General Assembly
14:00-14:30
Coffee break
14:30-15:15
Parallel Sessions
Session 17: Link between metabolism and cardiac dysfunction
Chairs: Loek van Heerebeek (Amsterdam, The Netherlands) & Zoltan Papp (Debrecen, Hungary)
Gilles De Keulenaer (Antwerpen, Belgium)
Effects of ERBB4 signaling across the spectrum of heart failure
Mathias Mericskay (Châtenay-Malabry, France)
Impact of NAD stimulation in the context of acute heart stress
Jérémy Fauconnier (Montpellier, France)
Diabetic mitochondria and cardiac arrhythmia
Session 18: Phosphodiesterase 2 (PDE2) in the heart - good or bad?
Chairs: Viacheslav Nikolaev (Hamburg, Germany) & Lise Román Moltzau (Oslo, Norway)
Jérôme Leroy (Châtenay-Malabry, France)
Gene therapy with PDE2 in heart failure
Michael Preedy (London, United Kingdom)
PDE2 inhibition in heart failure
Magnus Aronsen (Oslo, Norway)
PDE2 inhibition and ventricular arrhythmias
Session 19: Cardioprotection and Cardiotoxicity
Co-organised with SIRC and EU-CARDIOPROTECTION COST Action
Chairs: Pasquale Pagliaro (Turin, Italy) & Ioanna Andreadou (Athens, Greece)
Rosalinda Madonna (Chieti, Italy)
Novel molecular and cellular targets of tyrosin kinase inhibitors-induced cardiovascular toxicity
Gerd Heusch (Essen, Germany)
Coronary microvascular obstruction- the new frontier of cardioprotection
Rainer Schulz (Giessen, Germany)
Importance of comorbidities and risk factors in studies of cardioprotection
Session 20: Novel mechanisms of transcription regulation in cardiovascular disease
Co-organised with EU-CardioRNA COST Action symposium
Chairs: Emma Louise Robinson (Aurora, USA) & Yvan Devaux (Strassen, Luxembourg)
Johannes Backs (Heidelberg, Germany)
Metabolic regulation of the cardiac epigenome
Markéta Hlaváčková (Prague, Czech Republic)
The role of RNA-demethylase FTO in cardiac tolerance to ischemia-reperfusion injury
Monika Stoll (Maastricht, The Netherlands)
Long non-coding RNAs in atrial fibrillation
15:15-15:40
Coffee break
15:40-16:25
Parallel Sessions
Session 21: Targeting intermediary metabolism in heart failure
Chairs: Frank Lezoualc’h (Toulouse, France) & Friederike Cuello (Hamburg, Germany)
Matthias Dewenter (Würzburg, Germany)
The CaMKII-HDAC4 interface as a new drug target
Ajay Shah (London, United Kingdom)
Redox regulation of intermediary metabolism in the heart under stress
Hossein Ardehali (Chicago, IL, USA)
Targeting iron metabolism in heart failure
Session 22: Cytoskeleton modifications in cardiomyocyte homeostasis and disease
Sponsored by JMCC
Chairs: Jolanda van der Velden (Amsterdam, The Netherlands) & Wolfgang Linke (Münster, Germany)
Antoine Muchir (Paris, France)
Microtubule modifications in cardiomyopathy caused by A-type lamins gene mutations
Izhac Kehat (Haifa, Israel)
Spatiotemporal maintenance of sarcomeric mRNA and proteins
Giulio Agnetti (Baltimore, MD, USA)
Desmin modifications in heart failure
Session 23: Arrhythmias and sudden cardiac death
Chairs: Yael Yaniv (Haifa, Israel) & Elise Balse (Paris, France)
Carol Ann Remme (Amsterdam, The Netherlands)
Sodium channelopaties and sudden cardiac death: novel mechanisms and therapeutic strategies
Flavien Charpentier (Nantes, France)
Cardiac channelopathies in a dish
Alessandro Bertero (Seattle, WA, USA)
Chromatin topology dysregulation in cardiac laminopathy
Session 24: Immune response in cardiovascular disease
Chairs: Alessandra Ghigo (Turin, Italy) & Stephane Heymans (Maastricht, The Netherlands)
Antonio Abbate (Richmond, VA, USA)
The NLRP3 inflammasome in acute myocardial infarction
Daniela Carnevale (Rome, Italy)
Neuroimmune axis of cardiovascular control
Sabine Steffens (Munich, Germany)
Innate and adaptive immune response after myocardial infarction
16:25-16:55
Coffee break
16:55-17:30
Plenary Session 4 - ES-Servier Award - Poster and YI Awards
Chairs: Christoph Maack (ISHR-ES President-Elect), Mauro Giacca (ISHR-ES new President)
ISHR‐ES Servier Award Winner 2019
Jonathan Lambert (Padua, Italy)
Announcement of ISHR‐ES‐YI Awards
Announcement ISHR‐ES‐Poster Awards
17:30-18:00
Closing Session
Keynote Lecture
Chair: Emilio Hirsch (Turin, Italy)
Luigi Naldini (Milan, Italy)
Perspectives in gene therapy
Last update: 5 July 2021