ISHR 2021

36th Annual Meeting of the International Society for Heart Research
European Section

Online • 29 June - 1 July 2021

29 June - 1 July 2021


All times shown in the programme are

Right now, it is HH:mm (dd mmm 'YY) in Turin.



  • 09:15-09:30

    Opening ceremony

    Chairs: Lise Román Moltzau & Delphine Mika - ISHR Council Members


    "Early Career Investigators"

    Session 1
    Chairs: Bernadin Ndongson Dongmo (Oslo, Norway) & Angela Della Sala (Turin, Italy)

    Ana Louro (Oeiras, Portugal)

    Identification of the extracellular vesicle (EV) miRNome along human induced Pluripotent Stem Cell (hiPSC)-cardiomyocyte differentiation reveals a stemness maintenance cluster driving the superior in vitro bioactivity of hiPSC-EV in mediating cardiac repair

    Veneta Todorova (London, United Kingdom)

    Drug-based mobilisation of mesenchymal stem/progenitor cells (MSPCs) for long term improvement of cardiac function post MI

    Robert Johnson (Guildford, United Kingdom)

    Human myofibroblasts promote arrhythmia in human induced pluripotent stem cell-derived cardiomyocytes through independent paracrine and contact-mediated mechanisms

    Tim Stüdemann (Hamburg, Germany)

    Generation of human engineered heart tissue with light activated ion channels

    Marco Ronfini (Padua, Italy)

    Circulating muscle-derived miR-206 links skeletal muscle dysfunction to heart sympathetic denervation


    Coffee break


    "Early Career Investigators"

    Session 2
    Chairs: Julie Pires da Silva (Aurora, USA) & Matteo Sorge (Turin, Italy)

    Rima Kamel (Châtenay-Malabry, France)

    Gene therapy with PDE2A improves cardiac function and limits ventricular arrhythmias in a mouse model of heart failure

    Michele Russo (Turin, Italy)

    Phosphoinositide 3-kinase gamma is a master regulator of doxorubicin-induced metabolic rewiring of cardiomyocytes

    Theresa Brand (Würzburg, Germany)

    Defects in Ca2+ handling in phospholambanR9C mice impact on excitation/contraction coupling but also on mitochondria and ER

    Manuel Egle (Bern, Switzerland)

    Hypothermic oxygenated perfusion (HOPE) of donor cardiac grafts obtained after circulatory death (DCD) enhances vascular and contractile function by preserving endothelial NO production

    Dalma Kellermayer (Budapest, Hungary)

    Increased expression of N2BA titin corresponds to more compliant myofibrils in athlete’s heart


    Opening ceremony

    Chairs: Lucie Carrier (ISHR-ES President), Alessandra Ghigo and Emilio Hirsch (Organising committee)


    Plenary Session 1

    Ketty Shwartz Award 
    Chair: Lucie Carrier (Hamburg, Germany)

    Ursula Ravens (Freiburg, Germany)

    Cardiac electrical activity – Stretching the story of ion channels and arrhythmias


    Coffee break


    Parallel Sessions

    Session 1: Mitochondria as targets in cardiovascular disease
    Chairs: Rainer Schulz (Giessen, Germany) & Nina Kaludercic (Padua, Italy)

    Michael Murphy (Cambridge, United Kingdom)

    Mitochondrial ROS production in cardiac IR injury

    Derek Hausenloy (Singapore, Singapore)

    Targeting mitochondria for cardioprotection

    Christoph Maack (Würzburg, Germany)

    Ion and redox regulation as a cardioprotective strategy

    Session 2: New Frontiers in Cardiac Imaging
    Chairs: Silvio Aime (Turin, Italy) & Amedeo Chiribiri (London, United Kingdom)

    René Botnar (London, United Kingdom)

    Coronary MR angiography and plaque imaging: where are we today?

    Sandor Batkai (Hannover, Germany)

    US imaging of heart failure for drug development

    Fabien Hyafil (Paris, France)

    Imaging with PET: more than the LV to look at

    Session 3: Mid-Career Investigators (MCIs) Symposium
    Sponsored by MappingLab

    Chairs: Davor Pavlovic (Birmingham, United Kingdom) & Tania Zaglia (Padua, Italy)

    Sebastiano Sciarretta (Rome, Italy)

    Targeting autophagy in cardiovascular disease

    Monika Gladka (Amsterdam, The Netherlands)

    Novel mechanisms in cardiac regeneration

    Christina Molina (Hamburg, Germany)

    Novel mechanisms mediating atrial dysfunction

    Olivia Johnstone (Manchester, United Kingdom) · Sponsored talk

    Combined optical mapping of membrane potential and intracellular calcium to understand cardiac function

    Session 4: Single cell genomics and gene editing
    Sponsored by JMCC

    Chairs: Lucie Carrier (Hamburg, Germany) & Sian Harding (London, United Kingdom)

    Mauro Giacca (London, United Kingdom)

    A toolbox for cardiac gene editing

    Eva van Rooij (Utrecht, The Netherlands)

    Gene editing approaches in genetic cardiomyopathy

    Michela Noseda (London, United Kingdom)

    Single cell gene expression to understand the dynamic architecture of the heart


    Coffee break


    Short oral presentations/Poster Session

    Parallel group 1 (G1.01-G1.17)
    Committees: Frank Lezoualc’h (Toulouse, France), Sandrine Lecour (Cape Town, South Africa)

    Parallel group 2 (G2.01-G2.16)
    Committees: Christoph Maack (Würzburg, Germany), Sean Davidson (London, United Kingdom)

    Parallel group 3 (G3.01-G3.17)
    Committees: Paula da Costa Martins (Maastricht, Netherlands), Yael Yaniv (Haifa, Israel)


    Coffee break


    Parallel Sessions

    Session 5: Mitochondrial Ion Handling
    Chairs: Peter Ferdinandy (Budapest, Hungary) & Jeanne Mialet-Perez (Toulouse, France)

    Diego De Stefani (Padua, Italy)

    Mitochondrial ATP-sensitive potassium channels (mitoKATP)

    John Elrod (Philadelphia, PA, USA)

    Mitochondrial signaling in myofibroblast formation and fibrosis

    Edoardo Bertero (Würzburg, Germany)

    MCU in Barth syndrome

    Session 6: Redox regulation of CV function
    Chairs: Petra Kleinbongard (Essen, Germany) & Derek Hausenloy (Singapore, Singapore)

    Katrin Schröder (Frankfurt, Germany)

    NADPH oxidases: the good and the bad

    Nina Kaludercic (Padua, Italy)

    Mitochondrial ROS and cardiac function: the Janus face of MAO

    Joseph Burgoyne (London, United Kingdom)

    From redox mechanisms to potential therapies

    Session 7: Microvasculature and pulmonary hypertension
    Chairs: Paula da Costa Martins (Maastricht, The Netherlands) & Michael Preedy (London, United Kingdom)

    Zamaneh Kassiri (Edmonton, AB, Canada)

    Disintegrin and metalloproteinases (ADAMs) as novel players in aortic aneurysm

    Ralph Schermuly (Giessen, Germany)

    Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

    Stephan Rosenkranz (Cologne, Germany)

    PI3K signaling in pulmonary hypertension

    Session 8: Extracellular vesicles and inflammatory mediators
    Chairs: Sean Davidson (London, United Kingdom) & Sveva Bollini (Genoa, Italy)

    Stephane Heymans (Maastricht, The Netherlands)

    Stabilin-1: a T-cell and macrophage function modulator in viral myocarditis

    Lucio Barile (Lugano, Switzerland)

    Roles of exosomes in myocardial Infarction: therapy delivery tools, therapeutic targets and potential biomarkers

    Ganglian Qin (Birmingham, AL, USA)

    miRNA in infarcted heart-derived exosomes

  • 13:00-14:00

    Plenary Session 2

    Lecture - Young Investigator Award
    Chairs: Lucie Carrier (Hamburg, Germany) & Rodolphe Fischmeister (Châtenay-Malabry, France)

    Jury: Christoph Maack (Würzburg, Germany), Lise Román (Moltzau, Oslo, Norway), Sean Davidson (London, United Kingdom), Zoltan Papp (Debrecen, Hungary)

    Nicolo Mangraviti (Maastricht, The Netherlands)

    LncRNA “Bigheart” controls a transcriptional program that auto-amplificate calcineurin-NFAT signalling in cardiac hypertrophy

    Anne-Sophie Colombe (Châtenay-Malabry, France)

    Anchored-PKA regulates connexin 43 GAP junction communication in the heart

    Edoardo Schneider (London, United Kingdom)

    High-throughput screening to identify human microRNAs that enhance CRISPR/Cas9-based cardiac precise gene editing

    Mathieu Panel (Montpellier, France)

    Impaired mitochondrial calcium homeostasis at the early stage of the diabetic cardiomyopathy and diastolic heart failure

    Julie Pires da Silva (Aurora, CO, USA)

    Serum from pediatric dilated cardiomyopathy patients promotes dysregulation of cardiolipin biosynthesis and mitochondrial dysfunction in primary cardiomyocytes


    Coffee break


    Parallel Sessions

    Session 9: Calcium signalling in heart diseases
    Sponsored by JMCC

    Chairs: Ana M. Gomez (Châtenay-Malabry, France) & David Eisner (Manchester, United Kingdom)

    Katharine Dibb (Manchester, United Kingdom)

    Alterations to calcium handling in the atria of the failing heart

    Jessica Sabourin (Orsay, France)

    Orai1 inhibition preserves left ventricular function after pressure overload in mice

    Jordi Heijman (Maastricht, The Netherlands)

    Calcium buffering in atrial fibrillation

    Session 10: New aspects of cardiac cGMP signaling
    Chairs: Finn Olav Levy (Oslo, Norway) & Rodolphe Fischmeister (Châtenay-Malabry, France)

    Julia Gorelik (London, United Kingdom)

    Cyclic nucleotide signaling from compartmented receptors

    Kjetil Wessel Andressen (Oslo, Norway)

    Targeted biosensors to measure localized cGMP responses

    David Paterson (Oxford, United Kingdom)

    cGMP signaling regulating cardiac sympathetic neurons

    Session 11: Microvasculature
    Sponsored by FUJIFILM VisualSonics

    Chairs: Sandrine Lecour (Cape Town, South Africa) & Petra Kleinbongard (Essen, Germany)

    Ingo Hilgendorf (Freiburg , Germany)

    Small cells big effects: platelets and their role in myocardial ischemia/reperfusion injury

    David Grieve (Belfast, United Kingdom)

    Endothelial reactive oxygen species signaling and cardiac remodelling

    Lina Badimon (Barcelona, Spain)

    The pathophysiological consequences of microvascular dysfunction in the heart

    Philippe Trochet (Amsterdam, The Netherlands) · Sponsored talk

    Novel tools for left ventricular cardiac function correlation with myocardial oxygen saturation level

    Session 12: Metabolic signaling in cardiovascular diseases
    Chairs: Thomas Krieg (Cambridge, United Kingdom) & Renéè Ventura-Clapier (Châtenay-Malabry, France)

    Laetitia Pereira (Châtenay-Malabry, France)

    Ca2+ signaling alteration in type 2 diabetes: is there gender differences?

    Heiko Bugger (Graz, Austria)

    Sirtuins and mitochondria

    Massimiliano Mazzone (Leuven, Belgium)

    Macrophage functions during ischemic and non-ischemic muscle repair


    Coffee break


    Short oral presentations/Poster Session

    Parallel group 4 (G4.01-G4.17)
    Committees: Nina Kaludercic (Padua, Italy), Lucie Carrier (Hamburg, Germany)

    Parallel group 5 (G5.01-G5.17)
    Committees: Lise Román Moltzau (Oslo, Norway), Zoltan Papp (Debrecen, Hungary)

    Parallel group 6 (G6.01-G6.16)
    Committees: Mauro Giacca (London, United Kingdom), Rodolphe Fischmeister (Châtenay-Malabry, France)


    Coffee break


    Parallel Sessions

    Session 13: Gene and protein regulation in cardiac disease
    Chairs: Alessandro Bertero (Seattle, USA) & Esther Creemers (Amsterdam, The Netherlands)

    Thomas Vondriska (Los Angeles, CA, USA)

    Targeting epigenomes in cardiovascular disease

    Wolfgang Linke (Münster, Germany)

    Posttranslational control of truncated titin proteins in cardiomyocytes from DCM patients

    Mirko Völkers (Heidelberg, Germany)

    mRNA metabolism and translational control in cardiovascular disease

    Session 14: Cancer and heart failure
    Chairs: Eric Morel (Châtenay-Malabry, France) & Pietro Ameri (Genoa, Italy)

    Wouters Meijers (Groningen, The Netherlands)

    Interplay between cardiovascular disease and cancer

    Gavin Oudit (Edmonton, AB, Canada)

    PI3Kalpha pathway inhibiton in Cardio-Oncology

    Paul Burridge (Chicago, IL, USA)

    Modeling cardiotoxicity with iPSC

    Session 15: Aging and regeneration
    Chairs: Mauro Giacca (London, United Kingdom) & Thomas Eschenhagen (ISHR-Intl President - Hamburg, Germany)

    Loren Field (Indianapolis, IN, USA)

    New concepts in cardiac regeneration – A historical perspective

    Nadia Mercader (Bern, Switzerland)

    Models to crack the code of organ regeneration

    Jeanne Mialet-Perez (Toulouse, France)

    Non-classical mechanisms of senescence in the aging heart

    Session 16: Protein modification in cardiac disease
    Sponsored by Ionoptix

    Chairs: Giulio Agnetti (Baltimore, USA) & Christoph Maack (Würzburg, Germany)

    Gary Lopaschuk (Edmonton, AB, Canada)

    Non-histone protein acetylation in the regulation of cardiac metabolism and function

    Luc Bertrand (Louvain, Belgium)

    Targeting O-GlcNAcylation to prevent cardiac hypertrophy development

    Friederike Cuello (Hamburg, Germany)

    Oxidant-mediated regulation of protein kinase activity

    Diederik Kuster (Amsterdam, The Netherlands) · Sponsored talk

    Kinase inhibitor screening to uncover novel modulators of contraction and relaxation


    Coffee break


    Plenary Session 3

    President Distinguished Lecture 
    Chair: Thomas Eschenhagen (ISHR-Intl President - Hamburg, Germany)

    Evangelia (Litsa) Kranias (Cincinnati, OH, USA)

    Calcium cycling circuits in cardiac function and survival

  • 13:00-14:00

    ISHR-ES General Assembly


    Coffee break


    Parallel Sessions

    Session 17: Link between metabolism and cardiac dysfunction
    Chairs: Loek van Heerebeek (Amsterdam, The Netherlands) & Zoltan Papp (Debrecen, Hungary)

    Gilles De Keulenaer (Antwerpen, Belgium)

    Effects of ERBB4 signaling across the spectrum of heart failure

    Mathias Mericskay (Châtenay-Malabry, France)

    Impact of NAD stimulation in the context of acute heart stress

    Jérémy Fauconnier (Montpellier, France)

    Diabetic mitochondria and cardiac arrhythmia

    Session 18: Phosphodiesterase 2 (PDE2) in the heart - good or bad?
    Chairs: Viacheslav Nikolaev (Hamburg, Germany) & Lise Román Moltzau (Oslo, Norway)

    Jérôme Leroy (Châtenay-Malabry, France)

    Gene therapy with PDE2 in heart failure

    Michael Preedy (London, United Kingdom)

    PDE2 inhibition in heart failure

    Magnus Aronsen (Oslo, Norway)

    PDE2 inhibition and ventricular arrhythmias

    Session 19: Cardioprotection and Cardiotoxicity
    Co-organised with SIRC and EU-CARDIOPROTECTION COST Action

    Chairs: Pasquale Pagliaro (Turin, Italy) & Ioanna Andreadou (Athens, Greece)

    Rosalinda Madonna (Chieti, Italy)

    Novel molecular and cellular targets of tyrosin kinase inhibitors-induced cardiovascular toxicity

    Gerd Heusch (Essen, Germany)

    Coronary microvascular obstruction- the new frontier of cardioprotection

    Rainer Schulz (Giessen, Germany)

    Importance of comorbidities and risk factors in studies of cardioprotection

    Session 20: Novel mechanisms of transcription regulation in cardiovascular disease
    Co-organised with EU-CardioRNA COST Action symposium

    Chairs: Emma Louise Robinson (Aurora, USA) & Yvan Devaux (Strassen, Luxembourg)

    Johannes Backs (Heidelberg, Germany)

    Metabolic regulation of the cardiac epigenome

    Markéta Hlaváčková (Prague, Czech Republic)

    The role of RNA-demethylase FTO in cardiac tolerance to ischemia-reperfusion injury

    Monika Stoll (Maastricht, The Netherlands)

    Long non-coding RNAs in atrial fibrillation


    Coffee break


    Parallel Sessions

    Session 21: Targeting intermediary metabolism in heart failure
    Chairs: Frank Lezoualc’h (Toulouse, France) & Friederike Cuello (Hamburg, Germany)

    Matthias Dewenter (Würzburg, Germany)

    The CaMKII-HDAC4 interface as a new drug target

    Ajay Shah (London, United Kingdom)

    Redox regulation of intermediary metabolism in the heart under stress

    Hossein Ardehali (Chicago, IL, USA)

    Targeting iron metabolism in heart failure

    Session 22: Cytoskeleton modifications in cardiomyocyte homeostasis and disease
    Sponsored by JMCC

    Chairs: Jolanda van der Velden (Amsterdam, The Netherlands) & Wolfgang Linke (Münster, Germany)

    Antoine Muchir (Paris, France)

    Microtubule modifications in cardiomyopathy caused by A-type lamins gene mutations

    Izhac Kehat (Haifa, Israel)

    Spatiotemporal maintenance of sarcomeric mRNA and proteins

    Giulio Agnetti (Baltimore, MD, USA)

    Desmin modifications in heart failure

    Session 23: Arrhythmias and sudden cardiac death
    Chairs: Yael Yaniv (Haifa, Israel) & Elise Balse (Paris, France)

    Carol Ann Remme (Amsterdam, The Netherlands)

    Sodium channelopaties and sudden cardiac death: novel mechanisms and therapeutic strategies

    Flavien Charpentier (Nantes, France)

    Cardiac channelopathies in a dish

    Alessandro Bertero (Seattle, WA, USA)

    Chromatin topology dysregulation in cardiac laminopathy

    Session 24: Immune response in cardiovascular disease
    Chairs: Alessandra Ghigo (Turin, Italy) & Stephane Heymans (Maastricht, The Netherlands)

    Antonio Abbate (Richmond, VA, USA)

    The NLRP3 inflammasome in acute myocardial infarction

    Daniela Carnevale (Rome, Italy)

    Neuroimmune axis of cardiovascular control

    Sabine Steffens (Munich, Germany)

    Innate and adaptive immune response after myocardial infarction


    Coffee break


    Plenary Session 4 - ES-Servier Award - Poster and YI Awards

    Chairs: Christoph Maack (ISHR-ES President-Elect), Mauro Giacca (ISHR-ES new President)

    ISHR‐ES Servier Award Winner 2019

    Jonathan Lambert (Padua, Italy)

    Announcement of ISHR‐ES‐YI Awards

    Announcement ISHR‐ES‐Poster Awards


    Closing Session

    Keynote Lecture
    Chair: Emilio Hirsch  (Turin, Italy)

    Luigi Naldini (Milan, Italy)

    Perspectives in gene therapy

Last update: 5 July 2021